How is biological shape encoded ? The immense diversity of shapes at the cellular, tissue and organismal scales begs the question of whether general principles underlie the emergence of shapes. In other words, what is the nature of the in-form-ation driving cell and tissue morphogenesis. This talk will address these questions in the context of Drosophila embryonic development.
It is well appreciated that genes encode shape though how they do so remains largely not understood. Exploring the dynamical features and mechanisms of tissue extension and tissue invagination in Drosophila gastrulation we will develop the notion that information rests on three pillars: genetics/biochemical activity, mechanics and geometry. We will contrast two general modalities of information flow driving morphogenesis: information executing a deterministic program and information resulting from self-organised, stochastic interactions across scales.
Speaker: Thomas Lecuit, Professor & Group Leader @ Collège de France, Paris and IBDM, Marseille
Host: Eduardo Moreno, Group Leader @ Cell Fitness Lab | Champalimaud Research